REVIEW OF ANTI-TNF MONOCLONAL ANTIBODY USE

Development of a Novel Inhibitory Chimeric Anti-HER2 Monoclonal Antibody

Mouse Anti-Tetracycline Monoclonal Antibody

Product Overview: Mouse monoclonal antibody to tetracycline. Immunogen: Tetracycline-KLH Conjugate Clone: K88Y88 Host animal: Mouse Source: Mouse Ascites Purity: Protein A Affinity Chromatography. Buffer: 0.01 moL/L pH 7.4 Phosphate Buffer Solution. Protein Content: 1 mg/mL Appearance: Clear Colorless Solution Introduction: Tetracycline is a broad-spectrum polyketide antibiotic produced by the ...

Anti-TNF antibody treatment of Crohn's disease.

Crohn’s disease and ulcerative colitis are the two idiopathic chronic inflammatory bowel diseases. Although these diseases may show substantial phenotypic overlap, it is widely accepted that these represent distinct pathogenic entities. The cause of neither ulcerative colitis nor Crohn’s disease is known, and genetic as well as environmental factors have been implicated. Previous reports implic...

Humanization and Characterization of an Anti-Human TNF-α Murine Monoclonal Antibody

A murine monoclonal antibody, m357, showing the highly neutralizing activities for human tumor necrosis factor (TNF-α) was chosen to be humanized by a variable domain resurfacing approach. The non-conserved surface residues in the framework regions of both the heavy and light chain variable regions were identified via a molecular modeling of m357 built by computer-assisted homology modeling. By...

Treatment with anti-TNF monoclonal antibody (c5N) reduces the extent of induced endometriosis in the baboon.

BACKGROUND Inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8 and tumour necrosis factor-alpha (TNF-alpha), are important in the pathogenesis of endometriosis. We assessed the efficacy of anti-TNF monoclonal antibody (mAb, c5N), known to prevent induced endometriosis in baboons, in reducing established endometriosis in baboons. METHODS This prospective, randomized, blinded, cont...